Detalhe da pesquisa
1.
Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss.
Endocrinology
; 148(11): 5175-85, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17656463
2.
Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
J Med Chem
; 50(21): 5202-16, 2007 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17887659
3.
Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes.
J Endocrinol
; 192(2): 371-80, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17283237
4.
Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal.
J Med Chem
; 49(25): 7545-8, 2006 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17149884
5.
A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: a potential therapy for type 2 diabetes.
Diabetes
; 51(5): 1453-60, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11978642
6.
Severe Alzheimer's disease: treatment effects on function and care requirements.
J Am Med Dir Assoc
; 12(2): 99-104, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21266285
7.
Engineering novel VPAC2-selective agonists with improved stability and glucose-lowering activity in vivo.
J Pharmacol Exp Ther
; 320(2): 900-6, 2007 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17110523
8.
A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents.
J Pharmacol Exp Ther
; 323(2): 692-700, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17671099
9.
PDE-10A inhibitors as insulin secretagogues.
Bioorg Med Chem Lett
; 17(10): 2869-73, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17400452
11.
Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonist.
J Biol Chem
; 281(18): 12506-15, 2006 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-16505481
12.
Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose.
J Pharmacol Exp Ther
; 315(3): 1396-402, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16162821